Abstract: The extraction of natural astaxanthin from shrimp wastes was studied. The extraction technology of astaxanthin with the vacuum cavitation was discussed in this article. The influences of extraction solvent, concentration of solvent, time and ventilation on extracting ratios were studied, and the best extraction parameters were obtained by orthogonal test. The extraction solvent was 80% ethanol, the extraction time was 35 minutes and the ventilation was 0.2 m3h-1. The effect and efficiency of the vacuum cavitations were compared with other cell-broken extraction in common use. It showed that the vacuum cavitations extraction is superior to others and it is a new extraction method fitting for industry.