Abstract: The disease of sanguinicolid trematodes (Sanguinicolidae) has a serious impact on the aquaculture of some commercial important fishes (tuna, amberjack, etc). It occurs once a year, and its prevalence needs a certain water temperature range. The rates of infection and death are usually high in cultured fishes. Sanguinicolids from the wild fishes can infect the cultured ones in the same sea area, leading to heavy economic losses. Here we reviewed the recent studies on this disease, including the hazards, epidemic features and integrated control methods used recently. At the same time we summarized the problems needed to be solved urgently. It can be a reference for further study on the control of the disease.