郑环宇, 高加龙, 章超桦, 司蕊, 郑惠娜, 曹文红, 秦小明. 华贵栉孔扇贝肉及其酶解产物对半去势雄性大鼠生殖能力的影响[J]. 南方水产科学, 2021, 17(3): 94-101. DOI: 10.12131/20200251
引用本文: 郑环宇, 高加龙, 章超桦, 司蕊, 郑惠娜, 曹文红, 秦小明. 华贵栉孔扇贝肉及其酶解产物对半去势雄性大鼠生殖能力的影响[J]. 南方水产科学, 2021, 17(3): 94-101. DOI: 10.12131/20200251
ZHENG Huanyu, GAO Jialong, ZHANG Chaohua, SI Rui, ZHENG Huina, CAO Wenhong, QIN Xiaoming. Effects of Chlamys nobilis and its enzymatic hydrolysates on reproductive capacity of hemi-castrated male rats[J]. South China Fisheries Science, 2021, 17(3): 94-101. DOI: 10.12131/20200251
Citation: ZHENG Huanyu, GAO Jialong, ZHANG Chaohua, SI Rui, ZHENG Huina, CAO Wenhong, QIN Xiaoming. Effects of Chlamys nobilis and its enzymatic hydrolysates on reproductive capacity of hemi-castrated male rats[J]. South China Fisheries Science, 2021, 17(3): 94-101. DOI: 10.12131/20200251

华贵栉孔扇贝肉及其酶解产物对半去势雄性大鼠生殖能力的影响

Effects of Chlamys nobilis and its enzymatic hydrolysates on reproductive capacity of hemi-castrated male rats

  • 摘要: 为探究华贵栉孔扇贝 (Chlamys nobilis) 肉及其酶解产物对改善男性生殖能力的功效,该研究以半去势SD雄性大鼠为动物实验模型,考察华贵栉孔扇贝肉及其酶解产物对半去势雄性大鼠的性行为表现、脏器系数、血清性激素水平、阴茎组织一氧化氮 (NO) 和总一氧化氮合酶 (NOS) 活力等的影响。结果表明,华贵栉孔扇贝肉及其酶解产物可缩短半去势雄性大鼠的勃起潜伏期 (P<0.01),增加扑捉次数 (P<0.05)、骑乘次数 (P<0.05) 等性行为表现;显著提升半去势雄性大鼠的睾丸、前列腺-精囊腺系数 (P<0.05),能显著提高半去势大鼠血清睾酮 (T) 含量,稳定黄体生成素 (LH) 和促卵泡激素 (FSH) 水平 (P<0.05);同时能显著介导NO和NOS的生成。综上,华贵栉孔扇贝肉及其酶解产物对半去势雄性大鼠的生殖能力有一定改善作用,其改善机制可能与调节半去势雄性大鼠血清性激素、促进阴茎信号因子的生成有关。

     

    Abstract: To explore the ameliorative effect of Chlamys nobilis and its enzymatic hydrolysates on male sexual function, we investigated the sexual behaviors, organ coefficient, level of serum sex hormone, NO contents and enzyme activity of NOS in penile tissue of the hemi-castrated male SD rats. The results show that C. nobilis and its enzymatic hydrolysates could increase the sexual behaviors of hemi-castrated male rats, such as catching frequency (P<0.05) and mount frequency (P<0.05); decrease the errection latency significantly (P<0.01); and increase the coefficients of testicular and prostate-seminal gland in hemi-castrated male rats significantly (P<0.05). Besides, it could increase the serum testosterone content, stable the levels of luteinizing hormone (LH) and follicle stimulating hormone (FSH). Moreover, it could mediate the production of NO and NOS in penile tissue significantly (P<0.05). Therefore, C. nobilis and its enzymatic hydrolysates can improve the reproductive capacity of hemi-castrated male rats, and the improvement mechanism is probably related to the regulation of serum sex hormones and the promotion of signal factors of penile tissue in hemi-castrated male rats.

     

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