Assessment of nitrofurazone and furazolidone residues in shrimp seedling

In order to study the metabolism and disposition of nitrofurazone and furazolidone in Penaeus vannamei seedling and assess the risks of their residual time and amount, we fed the shrimp seedling with nitrofurazone and furazolidone at concentration of 1 mgL-1.The ke of nitrofurazone is 0.04 h-1 and tl/2ke is 17.091 h for the shrimp seedling, and its metabolite SEM can be eliminated completely within 50 d. The ke of furazolidone is 0.045 h-1 andtl/2ke is 15.258 h, and the concentration of its metabolite AOZ is lower than the LOD within 20 d. The results indicate that use of nitrofurazone and furazolidone in shrimp seedlings cultivation with a therapeutic dose will not lead to residues in adult shrimp.